C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/62 (2006.01) C07D 307/33 (2006.01) C07K 14/035 (2006.01) C07K 14/195 (2006.01) C07K 14/28 (2006.01) C07K 14/47 (2006.01) C07K 19/00 (2006.01) C12N 15/12 (2006.01) C12N 15/31 (2006.01) C12N 15/38 (2006.01) C12N 15/67 (2006.01) C12N 15/85 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2391971
A transcriptional activator which comprises a fusion protein, the fusion protein comprising at least two polypeptide components, a first polypeptide component which binds in a sequence specific manner to an operator sequence in DNA, and a second polypeptide component, comprising a Lux-R transcription factor regulatory domain which binds cognate Acy1HSL or an analogue thereof, whereby upon binding of the Acy1HSL or analogue the DNA binding function of the first polypeptide component is activated; the transcriptional activator additionally comprising a third polypeptide component which activates transcription in eukaryotic cells.
L'invention concerne un activateur transcriptionnel comprenant une protéine de fusion, laquelle protéine comprend au moins deux constituants polypeptidiques, un premier constituant se liant à une séquence opérateur dans l'ADN de manière spécifique à la séquence, et un deuxième constituant polypeptidique comprenant un domaine de régulation du facteur de transcription Lux-R liant le AcylHLS parent ou un analogue. Lors de la liaison avec AcylHLS ou avec son analogue, la fonction de liaison à l'ADN du premier constituant polypeptidique est activée. L'activateur transcriptionnel comprend également un troisième constituant polypeptidique activant la transcription dans les cellules eucaryotes.
Cortese Riccardo
de Francesco Raffaele
Neddermann Petra
Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.p.a.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
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