Methods and means relating to retrotransposon and retroviral...

Details Methods and means relating to retrotransposon and retroviral... Methods and means relating to retrotransposon and retroviral...

G - Physics

01

N

G01N 33/50 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2277483

Ku (Ku70 and Ku80) of yeast and mammalian cells and other components of the Ku- associated DNA repair pathway are involved in retrotransposon and retroviral integration into cellular nucleic acid. Agents which inhibit activity of the pathway are useful for inhibition of retroviruses. Such agents are obtainable using assays involving the Ku-associated DNA repair pathway and one or more components thereof.

L'invention concerne le Ku (Ku70 et Ku80) de cellules de levure et de cellules mammaliennes, ainsi que d'autres constituants entrant dans la voie de réparation de l'ADN associée à Ku, intervenant dans l'intégration de rétrovirus et de rétrotransposon dans l'acide nucléique cellulaire. Des agents inhibant l'activité de cette voie de réparation sont utiles pour inhiber des rétrovirus. On peut obtenir ces agents au moyen de dosages faisant intervenir la voie de réparation de l'ADN associée à Ku, ainsi qu'un ou plusieurs de ses constituants.

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