G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/53 (2006.01) G01N 33/543 (2006.01) G01N 33/566 (2006.01) G01N 33/577 (2006.01) G01N 33/58 (2006.01)
Patent
CA 2417088
The present invention relates generally to a method for identifying molecules that bind the R7.1 epitope of LFA-1 or bind LFA-1 such that the R7.1 epitope is modified. The present invention further relates to a method for determining occupancy of the LFA-1 receptor by molecules that bind to the R7.1 epitope or bind LFA-1 such that the R7.1 epitope is modified after administration to a subject. The present invention further relates to molecules useful in the methods of the invention.
La présente invention concerne de façon générale un procédé pour identifier des molécules liant l'épitope R7.1 de la molécule LFA-1 ou liant la molécule LFA-1, de manière à modifier l'épitope R7.1. Cette invention concerne également un procédé pour déterminer l'occupation du récepteur de la LFA-1 par des molécules se liant à l'épitope R7.1 ou liant la LFA-1, de manière à modifier l'épitope R7.1 après leur administration à un sujet, ainsi que des molécules utiles dans les procédés de ladite invention.
Caviness Gary O.
Kishimoto Takashi
Lemieux Rene M.
Magolda Ronald L.
Reiser Hans C.
Boehringer Ingelheim Pharmaceuticals Inc.
Fetherstonhaugh & Co.
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