A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 38/17 (2006.01) A61K 39/00 (2006.01) A61K 47/42 (2006.01) A61P 35/00 (2006.01) C07K 14/47 (2006.01) C12Q 1/34 (2006.01) C12Q 1/42 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2477417
In one aspect, the invention provides methods for determining the biological activity of heat shock proteins or heat shock protein-peptide complexes based on the ATPase activity or the multimeric structure of the heat shock proteins or heat shock protein-peptide complexes, and methods for screening agents that modulate the biological activity of heat shock proteins or heat shock protein- peptide complexes. In another aspect, the invention provides complexes, compositions and methods for enhancing the immunogenicity of a heat shock protein or a complex comprising a heat shock protein and an antigenic molecule.
Dans l'un de ses aspects, l'invention concerne des méthodes permettant de déterminer l'activité biologique de protéines de choc thermique ou de complexes de protéines-peptides de choc thermique en fonction de l'activité ATPase ou de la structure multimère desdites protéines de choc thermique ou desdits complexes de protéines-peptides de choc thermique; et des méthodes permettant de cribler des agents qui modulent l'activité biologique de ces protéines ou de ces complexes de protéines-peptides de choc thermique. Dans un autre aspect, l'invention concerne des complexes, des compositions et des méthodes améliorant l'immunogénicité d'une protéine de choc thermique ou d'un complexe comprenant une protéine de choc thermique et une molécule antigène.
Liu Chuanliang
Monks Stephen A.
Srivastava Pramod K.
Wasserman Andrew
Zabrecky James R.
Antigenics Inc.
Osler Hoskin & Harcourt Llp
University Of Connecticut Health Center
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