Methods and products for facile microbial expression of dna...

Details Methods and products for facile microbial expression of dna... Methods and products for facile microbial expression of dna...

C - Chemistry, Metallurgy

12

N

530/13, 195/1.2,

C12N 15/18 (2006.01) A61K 38/27 (2006.01) C07K 14/61 (2006.01) C12N 15/10 (2006.01)

Patent

CA 1340371

Disclosed is a method for constructing a DNA sequence encoding a desired polypeptide in such a manner as to insure that, on transcription in an appropriate host, the corresponding messenger RNA demonstrates levels of conformational structure insufficient to interfere with its accessibility for efficient ribosomal translation. The production of bovine growth hormone is illustrative of the invention.

411650

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