Methods and products for manipulating uncoupling protein...

A - Human Necessities – 61 – K

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A61K 39/395 (2006.01) A61K 31/7088 (2006.01) A61K 47/48 (2006.01) A61K 48/00 (2006.01) A61P 31/00 (2006.01) A61P 33/00 (2006.01) A61P 35/00 (2006.01) A61P 37/02 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) G01N 33/50 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2375508

The invention is based in part on the discovery that uncoupling proteins (UCPs) are expressed in the plasma membrane of rapidly dividing cells but not of growth arrested, chemotherapy resistant cells. It has also been found according to the invention that UCP is expressed in the lysosomal membrane under certain metabolic conditions. Thus the invention is methods, products, screening assays and kits relating to the manipulation of UCP expression within cellular and intracellular membranes.

L'invention repose en partir sur la découverte que des protéines UCP s'expriment dans la membrane plasmatique des cellules à division rapide et non dans celle des cellules à croissance bloquée, résistant à la chimiothérapie. On a également trouvé selon l'invention que l'UCP s'exprime dans la membrane lysosomale sous certaines conditions métaboliques. L'invention porte ainsi sur des procédés, des produits, des essais et nécessaires de recherche systématique se rapportant à la manipulation des UCP dans les membranes cellulaires et intracellulaires.

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