Methods and products for sealing a fluid leak in a tissue

Details Methods and products for sealing a fluid leak in a tissue Methods and products for sealing a fluid leak in a tissue

A - Human Necessities

61

K

A61K 38/39 (2006.01) A61K 38/36 (2006.01) A61L 24/10 (2006.01)

Patent

CA 2254898

Methods and products for rapidly sealing a fluid leak in a tissue are provided. A polymerizable protein is applied to a tissue having an opening which creates a fluid leak in the tissue, in order to seal the opening. The tissue area and opening coated with the polymerizable protein are exposed to an initiator in order to polymerize the covering in situ, and create a seal over the opening that prevents fluid leakage. The methods and products to the invention may be used, for example, to seal airholes in lung injuries and to seal anastomoses and suture lines for blood vessels.

Procédés et produits permettant de bloquer rapidement et de manière étanche une fuite de fluide dans un tissu. Une protéine polymérisable est appliquée sur un tissu présentant une ouverture, ce qui provoque une fuite de fluide du tissu, afin de fermer de manière étanche ladite ouverture. La zone tissulaire et l'ouverture recouvertes de la protéine polymérisable sont exposées à un initiateur destiné à polymériser le bouchon protéique in situ et à créer une fermeture étanche de l'ouverture pour empêcher la fuite de fluide. Les procédés et produits de la présente invention peuvent être utilisés, par exemple, pour fermer de manière étanche des perforations laissant passer l'air dans des blessures pulmonaires, ainsi que des anastomoses et des sutures de vaisseaux sanguins.

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