Methods and products for treating proliferative diseases

Details Methods and products for treating proliferative diseases Methods and products for treating proliferative diseases

A - Human Necessities

61

K

A61K 31/4409 (2006.01) A61K 31/7004 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2730773

Methods and products for treating proliferative diseases, and wounds, using as a pharmacon an autophagy inhibitor, a glycolytic inhibitor, and/or an agent able to alter cellular production of reactive oxygen, or combination thereof, optionally in combination with one or more chemotherapeutic agents. In some embodiments, the invention combines a 4-aminoquinoline, exemplified by chloroquine, with a glycolytic inhibitor, exemplified by 2-deoxy-D-glucose and anti-VEGF antibodies. The systems and methods of the invention may be used to treat drug-resistant or multi-drug resistant cancers.

La présente invention concerne des procédés et des produits pour traiter des maladies prolifératives, et des plaies, en utilisant en tant que pharmacon un inhibiteur dautophagie, un inhibiteur glycolytique, et/ou un agent capable daltérer la production cellulaire doxygène réactif, ou une combinaison de ceux-ci, éventuellement en combinaison avec un ou plusieurs agents chimiothérapeutiques. Dans certains modes de réalisation, linvention combine une 4-aminoquinoléine, exemplifiée par la chloroquine, avec un inhibiteur glycolytique, exemplifié par le 2-désoxy-D-glucose et des anticorps anti-VEGF. Les systèmes et procédés de linvention peuvent être utilisés pour traiter des cancers pharmacorésistants ou multirésistants aux médicaments.

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