Methods and reagents for cell transplantation

Details Methods and reagents for cell transplantation Methods and reagents for cell transplantation

C - Chemistry, Metallurgy

12

N

C12N 5/077 (2010.01) C12N 5/071 (2010.01) A61K 35/34 (2006.01) A61K 35/12 (2006.01)

Patent

CA 2443993

The invention features methods for producing cells for transplantation into myocardial tissue of a mammal (e.g., a human). The method includes the steps of (a) providing a population of bone marrow stem cells; (b) culturing the cells under conditions that induce the cells to become cardiomyogenic cells; (c) monitoring the state of differentiation of the cells of step (b); and (d) collecting the cells of step (b) when at least about 10% and as many as 100% of the cells are cardiomyogenic cells. The bone marrow stem cells can be, for example, human bone marrow stem cells. In one embodiment, the method includes the step of transplanting the differentiated stem cells into a mammal (e.g., a human).

L'invention concerne des méthodes permettant de produire des cellules destinées à une transplantation dans le tissu myocardique d'un mammifère (par exemple, un humain). Ladite méthode consiste a) à fournir une population de cellules souches de moelle osseuse; b) à cultiver ces cellules dans des conditions induisant la différenciation desdites cellules en cellules cardiomyogéniques; c) à surveiller la phase de différentiation des cellules de l'étape (b); et à d) collecter les cellules de l'étape b) lorsqu'au moins 10% à 100% des cellules sont des cellules cardiomyogéniques. Les cellules souches de moelle osseuse peuvent être, par exemple, des cellules souches de moelle osseuse humaine. Dans un mode de réalisation, cette méthode consiste à transplanter les cellules souches différentiées dans un mammifère (par exemple, un humain).

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