Methods and reagents for detecting increased risk of...

Details Methods and reagents for detecting increased risk of... Methods and reagents for detecting increased risk of...

C - Chemistry, Metallurgy

12

Q

C12Q 1/68 (2006.01) A61P 29/00 (2006.01) C12N 15/10 (2006.01) C12P 19/34 (2006.01)

Patent

CA 2365669

The present invention relates to methods for reliably detecting an increased risk of developing an inflammatory disorder in a mammalian patient (e.g., a human being) by detecting at least one copy of an IL-1.beta. gene haplotype in the patient comprising cytosine nucleotides at positions -31 and +3953. Also provided are kits for performing such methods. In addition, methods for detecting patients who require a higher dosage of an agent that reduces the effect of IL-1.beta. are also provided.

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