C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/861 (2006.01)
Patent
CA 2758592
The present invention provides a biosafe and useful vector to transfer genetic material to CD 14+ mononuclear cells (monocytes and monocyte-derived macrophages) in an efficient and specific manner. The embodiment of the invention makes use of the chimeric human adenovirus vectors 5 carrying the short fiber of enterotropic Ad40 to transfer genetic material to the target CD14+ mononuclear cells.
La présente invention concerne un vecteur efficace et fiable au plan de la biosécurité, permettant le transfert d'un matériel génétique vers des cellules mononucléaires CD 14+ (monocytes et macrophages dérivés de monocytes) de manière efficace et spécifique. Le mode de réalisation de l'invention utilise les vecteurs adénoviraux humains chimériques 5 portant la fibre courte d'Ad40 entérotropique pour transférer le matériel génétique vers les cellules mononucléaires CD 14+ cibles.
Chillon Rodriguez Miguel
Fernandez Gimeno Ester
Gassull Duro Miquel Angel
Rio Fernandez Adolfo
Fundacio Institut D'investigacio En Ciencies de La Salut Germans
Fundacio Privada Institucio Catalana de Recerca I. Estudis Avanc
Grifols S.a.
Robic
Universitat Autonoma de Barcelona
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