Methods and reagents for increasing proliferative capacity...

Details Methods and reagents for increasing proliferative capacity... Methods and reagents for increasing proliferative capacity...

C - Chemistry, Metallurgy

12

N

C12N 15/09 (2006.01) A61K 31/00 (2006.01) A61K 35/12 (2006.01) A61K 38/17 (2006.01) A61K 45/06 (2006.01) A61P 17/02 (2006.01) C07K 14/47 (2006.01) C12N 5/00 (2006.01) C12N 9/12 (2006.01) C12N 15/10 (2006.01) C12N 15/63 (2006.01)

Patent

CA 2352486

The present invention relates to methods and reagents for extending the life- span, e.g. the number of mitotic divisions, of a cell. In general, the subject method relies on the activation of a telomerase activity and inhibition of one or both of an Rb/p16 pathway or a p53 pathway.

La présente invention concerne des méthodes et des réactifs destinés à prolonger la durée de vie, c'est-à-dire, le nombre de divisions mitotiques d'une cellule. D'une manière générale, la méthode de l'invention se base sur l'activation d'une activité de télomérase et l'inhibition d'une voie Rb/p16 et/ou d'une voie p53.

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