Methods and reagents for inhibiting angiogenesis

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) A61P 9/00 (2006.01) A61P 35/00 (2006.01) C07K 14/075 (2006.01) C07K 14/47 (2006.01) C12N 15/62 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01) C12N 15/867 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2363139

Disclosed are methods for inhibiting angiogenesis using cyclin dependent kinase inhibitors (CDKi) and fusion proteins thereof, recombinant viruses comprising transgenes and nucleic acid sequences encoding the same, and liposomes carrying the same as angiogenesis-inhibiting reagents.

L'invention concerne des méthodes permettant d'inhiber l'angiogenèse à l'aide d'inhibiteurs de la kinase dépendante des cyclines (CDKi) et de protéines de fusion de ceux-ci. Cette invention concerne également des virus recombinants comprenant des transgènes et des séquences d'acide nucléique codant pour ces derniers, ainsi que des liposomes porteurs de ces transgènes, lesquels font office de réactifs inhibant l'angiogenèse.

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