Methods and reagents for inhibiting cholesterol absorption...

Details Methods and reagents for inhibiting cholesterol absorption... Methods and reagents for inhibiting cholesterol absorption...

C - Chemistry, Metallurgy

12

P

C12P 21/08 (2006.01) A61K 39/395 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) C07K 16/46 (2006.01) C12N 5/12 (2006.01) G01N 33/566 (2006.01) G01N 33/573 (2006.01) G01N 33/92 (2006.01)

Patent

CA 2127230

ABSTRACT OF THE DISCLOSURE This invention relates to the human enzyme, pancreatic cholesterol esterase (PCE), and a receptor (PCER) for this protein expressed by cells of the intestinal lining. Specifically, the invention relates to the use of inhibitors of binding between PCE and PCER to reduce intestinal uptake of dietary cholesterol in humans. Antibodies, including antisera, and monoclonal and chimeric antibodies, and cell lines producing such antibodies, raised against the PCER protein or fragments or epitopes thereof, are also provided. The invention also relates to treatment of individuals with therapeutic drugs for the prevention of alleviation of disease states in a human related to cholesterol metabolism.

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