Methods and reagents for inhibiting proliferation of smooth...

Details Methods and reagents for inhibiting proliferation of smooth... Methods and reagents for inhibiting proliferation of smooth...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) A61P 9/00 (2006.01) C07K 14/075 (2006.01) C07K 14/47 (2006.01) C12N 15/62 (2006.01) C12N 15/86 (2006.01) C12N 15/861 (2006.01) C12N 15/867 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2371846

Disclosed are methods for using .DELTA.E1/.DELTA.E4 recombinant adenoviruses encoding cyclin dependent kinase inhibitors (CDKi's) as reagents for inhibiting smooth muscle cell proliferation. Also disclosed are recombinant lentiviruses encoding cyclin dependent kinase inhibitors (CDKi's).

L'invention concerne des méthodes d'utilisation des adénovirus recombinants .DELTA.E1/.DELTA.E4 codant pour les inhibiteurs de la kinase dépendante des cyclines (ou inhibiteurs CDKi) qui font office de réactifs pour inhiber la prolifération des cellules du muscle lisse. Cette invention concerne également des lentivirus recombinants codant pour ces inhibiteurs de la kinase dépendante des cyclines (ou inhibiteurs CDKi).

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