C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/00 (2006.01) A61K 35/14 (2006.01) A61K 38/00 (2006.01) C07H 1/00 (2006.01) C07H 5/00 (2006.01) C07H 7/00 (2006.01) C07H 17/00 (2006.01) C07K 14/065 (2006.01) C07K 14/47 (2006.01) C12P 21/06 (2006.01) G01N 1/00 (2006.01) G01N 21/00 (2006.01) G01N 21/75 (2006.01) G01N 21/76 (2006.01) G01N 33/00 (2006.01) G01N 33/50 (2006.01) G01N 33/53 (2006.01) G01N 33/536 (2006.01) G01N 33/542 (2006.01) G01N 33/567 (2006.01) A61K 48/00 (2006.01)
Patent
CA 2439532
The present invention relates to methods and reagents useful for inhibition of apoptosis. Specifically, the invention relates to methods to identify agents that is either pro-apoptotic or anti-apoptotic, especially by affecting the signal transduction pathways of BAK protein and/or M11L protein. The invention also provides business methods, diagnostic kits for identification of pro- or anti-apoptotic agents. Another aspect of the invention provides a method to identify M11L-interacting polypeptides using mass spectrometry.
La présente invention concerne des méthodes et des réactifs utiles pour l'inhibition de l'apoptose. Spécifiquement, l'invention concerne des méthodes permettant d'identifier des agents soit pro-apoptotiques soit anti-apoptotiques, notamment par affectation des voies de transduction du signal de la protéine BAK et/ou de la protéine M11L. L'invention concerne également des méthodes d'affaires, des kits de diagnostic destinés à l'identification d'agents pro ou anti-apoptotiques. Un autre aspect de l'invention concerne une méthode permettant d'identifier des polypeptides en interaction avec M11L utilisant la spectrométrie de masse.
Mcfadden Grant
Moran Michael F.
Bereskin & Parr Llp/s.e.n.c.r.l.,s.r.l.
Mds Proteomics Inc.
The John P. Robarts Research Institute
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