Methods and reagents for regulating telomere length and...

Details Methods and reagents for regulating telomere length and... Methods and reagents for regulating telomere length and...

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07H 21/00 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C07K 16/40 (2006.01) C12N 9/12 (2006.01) C12N 15/54 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2265913

Purified and recombinant proteins TPC2 and TPC3 and recombinant or synthetic oligonucleotides corresponding to those proteins or fragments thereof can be used to detect regulators of telomere length and telomerase activity in mammalian cells and for a variety of related diagnostic and therapeutic purposes.

L'invention porte sur des protéines TPC2 et TPC3 de recombinaison et purifiées ainsi que sur des oligonucléotides de recombinaison ou synthétiques correspondant à ces protéines ou à des fragments de celles-ci, ces protéines et oligonucléotides pouvant être utilisés pour détecter les régulateurs de la longueur des télomères et de l'activité de la télomérase dans des cellules mammaliennes, ainsi qu'à diverses fins thérapeutiques et diagnostiques connexes.

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