A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 35/76 (2006.01) A61K 47/26 (2006.01) A61K 47/36 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2510903
Agents and methods for enhancing recombinant virus transduction in the bladder epithelium are described. A first method involves contacting the luminal surface of the bladder with a composition comprising a transduction enhancing agent and an oncolytic virus. Alternatively, the luminal surface of the bladder can be contacted first with a pretreatment composition comprising a transduction enhancing agent and, subsequently, with a composition comprising an oncolytic virus. Bladder treatment compositions comprising a transduction enhancing agent and an oncolytic virus are also described.
L'invention concerne des agents et des procédés d'amélioration de la transduction virale dans l'épithélium de la vessie. Un premier procédé consiste à mettre la surface luminale de la vessie en contact avec une composition comprenant un agent améliorant la transduction et un virus oncolytique. Autrement, la surface luminale de la vessie peut être mise en contact d'abord avec une composition de prétraitement comprenant un agent améliorant la transduction et, par la suite avec une composition comprenant un virus oncolytique. Des compositions de traitement de la vessie, comprenant un agent améliorant la transduction et un virus oncolytique sont également décrites.
Frey David
Memarzadeh Bahram
Ramesh Nagarajan
Yu Dechao
Cell Genesys Inc.
Cold Genesys Inc.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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