Methods and reagents for the rapid and efficient isolation...

Details Methods and reagents for the rapid and efficient isolation... Methods and reagents for the rapid and efficient isolation...

G - Physics

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G01N 33/574 (2006.01) B03C 1/01 (2006.01) C12Q 1/06 (2006.01) G01N 33/52 (2006.01) G01N 33/543 (2006.01) G01N 33/577 (2006.01) G01N 33/58 (2006.01) H01F 1/00 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2320418

A highly sensitive assay is disclosed which combines immunomagnetic enrichment with multiparameter flow cytometric and immunocytochemical analysis to detect, enumerate and characterize carcinoma cells in the blood. The assay can detect one epithelial cell or less in 1 ml of blood and has a greater sensitivety than conventional PCR or immunohistochemistry by 1-2 orders of magnitude. In addition, the assay facilitates the biological characterization and staging of carcinoma cells.

L'invention concerne une méthode de dosage hautement sensible qui combine un enrichissement immunomagnétique et une analyse cytométrique et immunocytochimique multiparamètre de débit pour détecter, dénombrer et caractériser des cellules cancéreuses dans le sang. Ce dosage est capable de détecter une cellule épithéliale ou moins dans 1 ml de sang et possède une sensibilité supérieure à celle de la technique PCR classique ou de l'immunohistochimie selon un ordre de grandeur de 1 à 2. De plus, ce dosage facilite la caractérisation biologique et la classification de cellules cancéreuses.

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