C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 15/30 (2006.01) A61K 39/00 (2006.01) A61K 39/015 (2006.01) A61K 39/145 (2006.01) A61K 39/21 (2006.01) A61K 39/39 (2006.01) A61K 45/00 (2006.01) C07K 14/16 (2006.01) C07K 14/445 (2006.01) C12N 15/86 (2006.01)
Patent
CA 2293692
New methods and reagents for vaccination are described which generate a CD8 T cell immune response against malarial and other antigens such as viral and tumour antigens. Novel vaccination regimes are described which employ a priming composition and a boosting composition, the boosting composition comprising a non-replicating or replication-impaired poxvirus vector carrying at least one CD8 T cell epitope which is also present in the priming composition.
On décrit de nouveaux procédés et de nouveaux réactifs de vaccination qui génèrent une réponse immunitaire des cellules T CD8 contre des antigènes de la malaria et d'autres antigènes tels que des antigènes de virus et de tumeur. On décrit de nouveaux protocoles de vaccination dans lesquels on utilise une composition d'amorces et une composition d'activation, cette dernière comprenant un vecteur du virus pox non réplicant ou à réplication altérée portant au moins un épitope de cellules T CD8 qui est également présent dans la composition d'amorces.
Blanchard Tom
Gilbert Sarah Catherine
Hanke Tomas
Hill Adrian Vivian Sinton
Mcmichael Andrew James
Kirby Eades Gale Baker
Oxxon Pharmaccines Limited
Oxxon Therapeutics Limited
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