Methods and reagents relating to inflammation and apoptosis

Details Methods and reagents relating to inflammation and apoptosis Methods and reagents relating to inflammation and apoptosis

C - Chemistry, Metallurgy

07

K

C07K 16/18 (2006.01) A61K 39/395 (2006.01) C07K 14/35 (2006.01) C07K 14/525 (2006.01) C07K 14/715 (2006.01) C07K 19/00 (2006.01) C12N 9/12 (2006.01) C12N 15/63 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2494276

The present invention relates to, among other embodiments, protein complexes which include tumor necrosis factor alpha (TNF-.alpha.) and/or tumor necrosis factor alpha receptor (TNFR). Preferably, the complexes comprise at least one polypeptide selected from the group consisting of: NF-~B activating kinase (NAK), RasGAP3, TRCP1, and TRCP2. The present invention further provides assays of identifying a compound for modulating the stability and activity of the complex. Also provided are methods of modulating apoptosis and inflammation, as well as treating TNF-.alpha. related diseases.

La présente invention concerne, parmi d'autres aspects, des complexes protéiques qui contiennent le facteur alpha de nécrose tumorale (TNF-.alpha.) et / ou le récepteur du facteur alpha de nécrose tumorale (TNFR). De préférence, lesdits complexes comprennent au moins un polypeptide choisi dans le groupe constitué de la kinase activant NF-.kappa.B (NAK), de RasGAP3, de TRCP1 et de TRCP2. La présente invention concerne en outre des analyses destinées à identifier un composé modulant la stabilité et l'activité dudit complexe. Elle concerne encore des méthodes de modulation de l'apoptose et de l'inflammation, ainsi que des méthodes de traitement de maladies liées à TNF-.alpha..

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