Methods and related compositions using specific flavonoids...

A - Human Necessities – 61 – K

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A61K 38/47 (2006.01) A61K 31/198 (2006.01) A61K 31/202 (2006.01)

Patent

CA 2699521

The present invention relates generally to methods and related compositions using flavonoids and/or indanes extracted from the stems and leaves of C. quadrangularis to reduce weight and inhibit lipase, .alpha.-amylase and .alpha.-glucosidase activity in mammals. By example and not by way of limitation, embodiments of the present disclosure, a composition and related methods for reducing body weight and/or inhibiting any combination of lipase, .alpha.-amylase and .alpha.-glucosidase is provided. The composition contains an effective amount of one or more flavonoids or indanes selected from 3-0--rhamnopyranosylkaempferol, 3-(4-hydroxybenzylidene)-2-(2, 5--dihydroxyphenyl)-1-(4-hydroxyphenyl)indane-4,6-diol, quercitrin, rhamnitrin, rhamnocitrin, quercitrin-3 -0"-acetate and parthenocissin A.

La présente invention concerne des procédés et des compositions connexes utilisant des flavonoïdes et/ou des indanes extraits des tiges et des feuilles de C. quadrangularis afin de diminuer le poids et de limiter l'activité de la lipase, de l'a-amylase et de l'a-glucosidase chez les mammifères. Par exemple et sans que cela soit limitatif, des modes de réalisation de la présente invention concernent une composition et des procédés connexes destinés à diminuer le poids corporel et/ou à empêcher toute combinaison de lipase, d'a-amylase et d'a-glucosidase. La composition contient une quantité efficace d'un ou de plusieurs flavonoïdes ou d'indanes sélectionnés parmi le 3-0- rhamnopyranosylkaempférol, le 3-(4-hydroxybenzylidène)-2-(2,5- dihydroxyphényl)-1-(4-hydroxyphényl)indane-4,6-diol, la quercitrine, la rhamnitrine, la rhamnocitrine, le quercitrine-3-0'-acétate et la parthénocissine A.

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