Methods and substances for preventing and treating...

Details Methods and substances for preventing and treating... Methods and substances for preventing and treating...

C - Chemistry, Metallurgy

12

N

C12N 15/00 (2006.01) A01H 5/00 (2006.01) C07K 14/28 (2006.01) C07K 14/62 (2006.01) C12N 9/88 (2006.01) C12N 15/36 (2006.01) C12N 15/82 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2326373

A plant-based edible vaccine against autoimmune disease prepared by expressing a CTB-autoantigen chimeric gene construct in plant cells and transgenic plants is disclosed. DNA constructs, expression vectors comprising a nucleotide sequence that encodes a CTB-autoantigen chimeric gene, which are optimized for expression in plants, are described.

L'invention se rapporte à un vaccin végétal sous forme comestible qui est dirigé contre les maladies auto-immunes et que l'on prépare en exprimant un produit de synthèse de gène chimère autoantigène de la toxine cholérique B dans des cellules végétales et des plantes transgéniques. L'invention se rapporte également à des produits de synthèse d'ADN et à des vecteurs d'expression comportant une séquence nucléotidique qui code pour un gène chimère autoantigène de la toxine cholérique B, qui sont optimisés en vue de leur expression dans des plantes.

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