Methods and system for the identification and...

G - Physics – 01 – N

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G01N 33/68 (2006.01) G06F 19/00 (2006.01)

Patent

CA 2553172

The invention provides methods and a system implementing these methods for identifying and characterizing peptides and their functional relationships by use of measures of correlation. These methods are based on the interaction of a Correlation Associated Network Module with several Application Modules including a Sequence Network Module, a Differential Network Module, a Marker Panel Network Module and a Surrogate Network Module allowing e.g. the provision of a representative overview of the peptide content of biological samples, the prediction of peptide sequences, the identification of peptides suitable to be used as marker panels and the identification of peptides suitable as surrogates for a known peptide.

L'invention concerne des procédés et un système mettant en oeuvre ces procédés, destinés à l'identification et à la caractérisation de peptides et de leurs rapports fonctionnels, utilisant des mesures de corrélation. Ces procédés sont fondés sur l'interaction entre un module de réseau associé de corrélation et plusieurs modules d'application, dont, notamment, un module de réseau de séquence, un module de réseau différentiel, un module de réseau d'ensembles de marqueurs et un module de réseaux de substituts, et permettant, par exemple, d'obtenir une vue d'ensemble représentative du contenu peptidique d'échantillons biologiques, de prévoir des séquences peptidiques, d'identifier des peptides pouvant être utilisés comme ensembles de marqueurs et d'identifier des peptides pouvant être utilisés comme substituts pour un peptide connu.

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