G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/53 (2006.01) C07K 1/00 (2006.01) C07K 7/00 (2006.01) G01N 33/566 (2006.01) G01N 33/569 (2006.01) C12N 5/06 (2006.01)
Patent
CA 2501864
The invention is based on the discovery that MHC class I and class II monomers immobilized to a solid surface are still capable of forming complexes with suitable MHC-binding peptides. Methods for detecting peptide binding to HLA monomers, and methods for measuring the relative degree of binding between two MHC-binding peptides as well as a method of measuring the rate of dissociation of peptides from MHC complexes are provided. The present invention also provides systems and kits useful for conducting the methods of the invention.
L'invention se rapporte à la découvert indiquant que des monomères de classe I et de classe II du complexe majeur d'histocompatibilité (CMH) immobilisés sur une surface solide sont encore capables de former des complexes avec des peptides de liaison au CMH appropriés. L'invention se rapporte à des procédés de détection de monomères peptidiques se liant au HLA, et à des procédés de mesure du degré relatif de liaison entre deux peptides de liaison au CMH ainsi qu'à un procédé de mesure de la vitesse de dissociation des peptides à partir de complexes du CMH. La présente invention se rapporte à des systèmes et à des trousses permettant la mise en oeuvre des procédés décrits ci-dessus.
Monseaux Sylvain
Montero-Julian Felix A.
Beckman Coulter Inc.
Osler Hoskin & Harcourt Llp
LandOfFree
Methods and systems for detecting mhc class i and class ii... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Methods and systems for detecting mhc class i and class ii..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Methods and systems for detecting mhc class i and class ii... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1586019