Methods and systems for neural maintenance and regeneration

Details Methods and systems for neural maintenance and regeneration Methods and systems for neural maintenance and regeneration

A - Human Necessities

61

K

A61K 31/7076 (2006.01) A61K 9/00 (2006.01) A61L 31/16 (2006.01) A61M 37/00 (2006.01) A61P 27/00 (2006.01)

Patent

CA 2611715

Methods and systems are described that release one or both of a neurotrophin and an inhibitor of the degradation of the neurotrophin within or in the vicinity of a highly innervated tissue. In some embodiments, the method includes regulating the release of the neurotrophin and the inhibitor of degradation over time. In some embodiments, the method includes monitoring the concentration of the neurotrophin over time. The system may include a device or multiple devices for the release of the neurotrophin and the inhibitor as well as a controller. In some embodiments the system may include a sensor device and/or an imaging device capable of detecting the concentration of the neurotrophin over time. The release of the neurotrophin and inhibitor of degradation may be part of a controlled release system and regulated over time.

L'invention concerne des procédés et des systèmes permettant de libérer une neurotrophine et/ou un inhibiteur de la dégradation de la neurotrophine dans un tissu fortement innervé ou à proximité de celui-ci. Dans certaines formes de réalisation, le procédé comporte l'étape consistant à réguler la libération de la neurotrophine et de l'inhibiteur de dégradation en fonction du temps. Dans certaines formes de réalisation, le procédé comporte l'étape consistant à surveiller la concentration de la neurotrophine en fonction du temps. Le système comprend un dispositif ou de multiples dispositifs de libération de la neurotrophine et de l'inhibiteur, ainsi qu'un organe de commande. Dans certaines formes de réalisation, le système comprend un dispositif de détection et/ou un dispositif d'imagerie permettant de détecter la concentration de la neurotrophine en fonction du temps. La libération de la neurotrophine et de l'inhibiteur de dégradation peut faire partie d'un système à libération contrôlée et être régulée en fonction du temps.

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