C - Chemistry – Metallurgy – 12 – P
Patent
C - Chemistry, Metallurgy
12
P
C12P 21/02 (2006.01) A61K 38/16 (2006.01) A61K 39/00 (2006.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C07K 14/22 (2006.01) C12N 9/10 (2006.01) C12N 15/54 (2006.01)
Patent
CA 2671709
Described herein are methods and systems for O-glycosylating proteins in vivo or in vitro in any prokaryotic organism. In these methods and systems, DNA comprising a gene that produces a PglL-like oligosaccharyltransferase and DNA comprising a gene that produces a protein to be O-glycosylated are used. The PglL-like oligosaccharyltransferase facilitates the covalent attachment of the glycan to the protein to produce theO-glycosylated protein. The methods and systems described herein provide an approach for the design and production of new vaccines and therapeutic agents for the treatment of various diseases.
L'invention porte sur des procédés et des systèmes pour la O-glycosylation de protéines in vivo ou in vitro dans n'importe quel organisme procaryote. Dans ces procédés et systèmes, l'ADN comportant un gène qui produit une oligosaccharyltransférase analogue à Pg1L et l'ADN comportant un gène qui produit une protéine devant être O-glycosylée sont utilisés. L'oligosaccharyltransférase analogue à Pg1L facilite la liaison covalente du glycane à la protéine pour donner la protéine O-glycosylée. Les procédés et systèmes décrits fournissent une approche pour la conception et la production de nouveaux vaccins et agents thérapeutiques pour le traitement de diverses maladies.
Faridmoayer Amirreza
Feldman Mario
Osler Hoskin & Harcourt Llp
The Governors Of The University Of Alberta
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