Methods and systems for operating an aerosol generator

A - Human Necessities – 61 – K

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A61K 9/12 (2006.01) A61K 9/72 (2006.01) A61K 31/7036 (2006.01) A61K 47/02 (2006.01) A61M 15/00 (2006.01) A61M 16/20 (2006.01)

Patent

CA 2599018

A method of treating a patient with a pulmonary disease, where the method includes delivering a dose of aerosolized medicament intermittently to a ventilator circuit coupled to the respiratory system of the patient. Also, a method of treating a patient with a pulmonary disease, where the method includes taking the patient off a ventilator, and administering to the patient, a nebulized aerosol comprising from about 100 µg to about 500 mg of a medicament. Additionally, an aerosolized medicament for the treatment of a pulmonary disease, where the medicament includes amikacin mixed with an aqueous solution having an adjusted pH from about 5.5 to about 6.3. The pH is adjusted by adding hydrochloric acid and sodium hydroxide to the aqueous solution.

L'invention concerne un procédé pour traiter un patient souffrant d'une maladie pulmonaire, le procédé consistant à administrer par intermittence une dose de médicament sous forme d'aérosol à un circuit de ventilateur couplé au système respiratoire du patient. L'invention concerne aussi un procédé pour traiter un patient souffrant d'une maladie de poumons, le procédé consistant à désaccoupler le ventilateur du patient et à administrer au patient un aérosol nébulisé comprenant entre environ 100 ?g et environ 500 mg d'un médicament. De plus, l'invention concerne un médicament sous forme d'aérosol destiné au traitement d'une maladie pulmonaire, le médicament comprenant l'amikacine mélangée avec une solution aqueuse ayant un pH ajusté entre environ 5,5 et environ 6,3. Le pH est ajusté par l'ajout d'acide hydrochlorique et d'hydroxyde de sodium à la solution aqueuse.

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