Methods and systems for prognosis and treatment of solid tumors

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2588253

The present invention provides methods, systems and equipment for the prognosis and treatment of renal cell carcinoma (RCC) or other solid tumors. Genes prognostic of clinical outcomes of a solid tumor can be identified according to the present invention. The expression profiles of these genes in peripheral blood mononuclear cells (PBMCs) of patients who have the solid tumor are correlated with clinical outcome of these patients. Examples of RCC prognosis genes are illustrated in Tables 2 and 3. These genes can be used as surrogate markers for predicting clinical outcome of an RCC patient of interest. These genes can also be used for the selection of a favorable treatment for an RCC patient of interest.

L'invention concerne des méthodes, des systèmes et un équipement permettant de pronostiquer et de traiter un hypernéphrome (RCC) ou d'autres tumeurs solides. Le pronostic génétique des avantages cliniques d'une tumeur solide peut être identifiée grâce à la présente invention. Les profils d'expression de ces gènes dans les cellules mononucléaires du sang périphérique de patients présentant la tumeur solide sont corrélés avec les avantages cliniques de ces patients. Des exemples de gènes de pronostic de l'hypernéphrome sont illustrés dans les Tables 2 et 3. Ces gènes peuvent être utilisés comme marqueurs substituts afin de prédire le résultat clinique d'un patient d'intérêt souffrant d'un hypernéphrome. Ces gènes peuvent également être utilisés pour la sélection d'un traitement favorable pour un patient d'intérêt souffrant d'un hypernéphrome.

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