Methods and systems for solution based sequence enrichment...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01)

Patent

CA 2699835

The present invention provides novel methods and systems for capturing and enrichment of target nucleic acids for reducing the complexity of target nucleic acids, preferably a genomic sample, for further analysis such as direct DNA sequencing, resequencing or SNP calling. In particular, the present invention provides for the enrichment of targeted sequences in a solution based format.

La présente invention porte sur de nouveaux procédés et systèmes pour capturer et enrichir des acides nucléiques cibles pour réduire la complexité des acides nucléiques cibles, de préférence un échantillon génomique, pour une analyse complémentaire telle qu'un séquençage d'ADN direct, un reséquençage ou un appel SNP. En particulier, la présente invention porte sur l'enrichissement de séquences ciblées dans un format à base de solution.

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