Methods and systems of using exosomes for determining...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) G01N 33/53 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2743211

Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.

L'invention concerne des exosomes utilisés pour détecter des biomarqueurs destinés à des procédés de diagnostic associé à une thérapie ou de pronostic afin d'identifier des phénotypes, tels qu'un état pathologique ou une maladie, et le stade ou la progression d'une maladie. On peut utiliser des exosomes de cellule d'origine pour profiler des états physiologiques et déterminer des phénotypes. On peut utiliser des biomarqueurs ou des marqueurs provenant d'exosomes spécifiques d'une cellule d'origine pour déterminer des régimes de traitement pour des maladies, des états pathologiques, les stades d'une maladie et les stades d'un état pathologique et pour déterminer l'efficacité d'un traitement. On peut également utiliser des marqueurs provenant d'exosomes spécifiques d'une cellule d'origine pour identifier des maladies d'origine inconnue.

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