G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/573 (2006.01) C07K 16/40 (2006.01) G01N 33/558 (2006.01)
Patent
CA 2197452
The present invention discloses methods and test kits which provide the means for a reliable, sensitive and selective assessment of periodontal disease activity, peri-implantitis or HIV(+)-infection/AIDS-disease related periodontal diseases. The preferred methods and test kits are constructed to be easy and rapid chair-side tests. The invention is based on the preparation and use of monoclonal antibodies which recognize the active mammalian matrix metalloproteinase-8 (MMP-8) and is capable of differentiating between said active matrix metalloproteinase-8 and its inactive proform.
Procédés et nécessaires de test qui permettent de détecter de manière fiable, sensible et sélective une maladie périodontique, une péri-implantite ou des maladies périodontiques associées au sida ou à l'infection au VIH(+). Les procédés et nécessaires de test préférés sont conçus pour permettre des tests effectués sur-le-champ faciles et rapides. La présente invention est fondée sur l'utilisation d'anticorps monoclonaux qui reconnaissent la métalloprotéinase-8 (MMP-8) matricielle mammalienne active et sont capables de distinguer ladite métalloprotéinase-8 de sa proforme inactive.
Lundqvist Leila Christina
Sorsa Timo Arto
Tikanoja Sari Hannele
Bereskin & Parr
Oy Medix Biochemica Ab
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