A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 36/9068 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2626049
A method of treating cancer by targeting two proteases, MMP-9 and cathepsin B is provided. Therapeutic compositions comprising one or more plant extracts that inhibit MMP-9 and/or cathepsin B, which are capable of inhibiting neoplastic and/or endothelial cell migration, tumour growth, tumour-induced angiogenesis and/or metastasis are also provided. The therapeutic compositions of the invention can be used in the treatment of cancer, and, methods of inhibiting tumour growth, tumour metastasis, and/or tumour-induced angiogenesis using the therapeutic compositions alone or in combination with an anti-cancer agent are, therefore, also provided.
L'invention concerne une méthode destinée à traiter le cancer par ciblage de deux protéases, soit MMP-9 et la cathepsine B. L'invention concerne également des compositions thérapeutiques comprenant un ou plusieurs extraits de plantes inhibant MMP-9 et/ou la cathepsine B, ces compositions permettant d'inhiber la migration cellulaire néoplasique et/ou endothéliale, la croissance tumorale, l'angiogenèse induite par la tumeur et/ou la métastase. Les compositions thérapeutiques de l'invention peuvent être utilisées dans le traitement du cancer. Par conséquent, l'invention se rapporte en outre à des méthodes destinées à inhiber la croissance tumorale, la métastase tumorale et/ou l'angiogenèse induite par la tumeur au moyen de ces compositions, lesquelles sont utilisées séparément ou en combinaison avec un agent anticancéreux.
Biopharmacopae Design International Inc.
Mbm Intellectual Property Law Llp
LandOfFree
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