Methods and tools for detecting collagen degradation

Details Methods and tools for detecting collagen degradation Methods and tools for detecting collagen degradation

C - Chemistry, Metallurgy

12

Q

C12Q 1/02 (2006.01) C12Q 1/04 (2006.01) C12Q 1/24 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2564545

Fluorophore-labeled collagen covalently bound to a cell culture vessel can be used to assay collagen degradation by a variety of cell types, including osteoclasts and tumor cells. Such assays provide a high throughput platform for rapid screening of large numbers of potential modulators of, for example, tumor metastasis or osteoclast differentiation and/or function.

L'invention porte sur un collagène marqué par un fluorophore et lié de manière covalente à un réceptacle de culture cellulaire, ce collagène marqué pouvant être utilisé pour tester la dégradation du collagène imputable à différents types de cellules telles que les ostéoclastes et les cellules tumorales. Ces tests permettant d'avoir une plate-forme à haut rendement pour dépister rapidement de grand nombres de modulateurs potentiels de la métastase tumorale ou de la différenciation et/ou de la fonction des ostéoclastes, par exemple.

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