G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2658464
The present invention relates to compositions and methods for the treatment of neurodegenerative pathologies in which the cognitive functions are affected, as observed in Alzheimer's disease. More particularly, the invention presents a strategy for observing the activity and/or the efficacy of neuroprotective treatments in human clinical studies, which strategy is based on the biochemical dosage of certain platelet parameters, more specifically the soluble APP-alpha (s-APP-alpha) form of the precursor amyloid protein, and can consequently be realized by means of blood draws. The invention also relates to methods, tools, constructions and compositions which are suitable for the realization of said strategies.
La présente invention concerne des compositions et méthodes pour le traitement de pathologies neurodégénératives dans lesquelles les fonctions cognitives sont altérées, comme observé dans la maladie d'Alzheimer. Plus particulièrement, l'invention présente une stratégie pour suivre en clinique humaine l'activité et/ou l'efficacité de traitements neuro-protecteurs, basée sur le dosage biochimique de certains paramètres des plaquettes, plus particulièrement la forme APP soluble alpha (sAPPalpha) de la protéine précurseur amyloïde, et donc réalisable à partir de prélèvements sanguins. L'invention concerne également des méthodes, outils, constructions et compositions adaptées à la mise en oeuvre de ces stratégies.
Bourdin Jerome
Desire Laurent
Schweighoffer Fabien
Exonhit Therapeutics Sa
Robic
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