Methods and uses of the integrin alpha 10 chain, for...

A - Human Necessities – 61 – K

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A61K 38/17 (2006.01) A61K 38/16 (2006.01) A61P 9/10 (2006.01) C07K 14/705 (2006.01) G01N 33/68 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2488423

An antigen indicative of the presence of atherosclerotic plaque is provided. The antigen is used in a method for slowing or arresting progression and/or effecting regression of atherosclerotic plaque in a mammal, comprising administering to the mammal a binding agent having binding sites specific for said antigen of said mammal. Also included are methods for diagnosing a mammal who has a risk of developing atherosclerosis, comprising determining the amount of said antigen. Moreover, uses of said antigen for detection and diagnosing atherosclerosis is provided.

L'invention concerne un antigène indiquant la présence de la plaque d'athérosclérose. L'antigène est utilisé dans une méthode servant à ralentir ou à stopper la progression et/ou à provoquer la régression de la plaque d'athérosclérose chez un mammifère, consistant à administrer au mammifère un agent de liaison comprenant des sites de liaison spécifiques pour ledit antigène du mammifère. L'invention concerne également des méthodes servant à diagnostiquer un mammifère risquant de développer une athérosclérose, consistant à déterminer la concentration dudit antigène. Par ailleurs, l'invention concerne également des utilisations de cet antigène pour la détection et le diagnostic de l'athérosclérose.

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