Methods and vectors for generating asialylated immunoglobulins

Details Methods and vectors for generating asialylated immunoglobulins Methods and vectors for generating asialylated immunoglobulins

C - Chemistry, Metallurgy

12

N

C12N 15/85 (2006.01) A61K 39/395 (2006.01) C07K 16/00 (2006.01) C12N 9/24 (2006.01) C12N 15/56 (2006.01) C12P 21/00 (2006.01) C12P 21/08 (2006.01) G01N 33/53 (2006.01) C07K 1/22 (2006.01)

Patent

CA 2674239

The properties of an Fc-containing protein, for example, an antibody, are controlled by altering the sialylation of the oligosaccharides in the Fc region by transfecting the cell line expressing the Fc-containing protein with a vector sequence encoding a sialidase. The modified Fc-containing proteins have therapeutic utility in diseases or conditions in which it is desirable to control the affinity for one or more of the Fc.gamma.RI, Fc.gamma.RIIA, and Fc.gamma.RIIIA receptors, ADCC activity, macrophage or monocyte activation, serum half-life, and avidity.

L'invention concerne le contrôle des propriétés d'une protéine contenant un fragment Fc, par exemple, un anticorps, par modification de la sialylation des oligosaccharides dans la région du fragment Fc par transfection de la lignée cellulaire exprimant la protéine contenant le fragment Fc avec une séquence de vecteur codant pour une sialidase. Les protéines modifiées contenant le fragment Fc ont une utilité thérapeutique dans des maladies ou des conditions dans lesquelles il est souhaitable de contrôler l'affinité pour un ou plusieurs des récepteurs Fc.gamma.RI, Fc.gamma.RIIA, et Fc.gamma.RIIIA, l'activité ADCC, l'activation des macrophages ou des monocytes, la demi-vie sérique, et l'avidité.

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