C - Chemistry – Metallurgy – 12 – M
Patent
C - Chemistry, Metallurgy
12
M
C12M 3/00 (2006.01) C12M 3/02 (2006.01) C12M 3/06 (2006.01)
Patent
CA 2131385
Methods, compositions and devices are provided for the growth of human stem and/or hematopoietic cells in culture. Bi-oreactors (106) are provided in which diverse cell types are simultaneously- cultured in the presence of appropriate levels of nu-trients and growth factors substantially continuously maintained in the bioreactor (106) while removing undesirable metabolic products. This simultaneous culture of multiple cell types successfully reconstructs hematopoietic tissue ex vivo. Optionally, at least one growth factor is provided through excretion by transfected stromal cells, particularly heterologous cells. Means are pro-vided for maintaining the stromal cells (112) and hematopoietic cells (110) separately, and to allow for harvesting of both the ad-herent (110, 112) and non-adherent cells (114).
Emerson Stephen G.
Palsson Bernhard O.
Schwartz Richard M.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
The Regents Of The University Of Michigan
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