A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) C12Q 1/68 (2006.01) G01N 33/53 (2006.01)
Patent
CA 2741489
The present invention relates to compositions and methods for diagnosing, monitoring and/or treating disease (e.g., autoimmune or chronic inflammatory disease, heart disease and/or stroke). In particular, the present invention provides methods for diagnosing, monitoring and treating disease based upon detecting or altering (e.g., altering expression or methylation status of) disease proteins (e.g., CD70, CD40L, and/or KIR). The present invention also provides kits for detecting methylation status of disease proteins (e.g., CD70, CD40L, and/or KIR) and for diagnosing, monitoring and/or treating diseases (e.g., autoimmune or chronic inflammatory disease, heart disease and/or stroke).
La présente invention concerne des compositions et des procédés pour diagnostiquer, surveiller et/ou traiter une maladie (par exemple, une maladie inflammatoire auto-immune ou chronique, une maladie cardiaque et/ou un accident cérébrovasculaire). En particulier, la présente invention concerne des procédés pour diagnostiquer, surveiller et traiter une maladie basée sur la détection ou la modification (par exemple, la modification de lexpression ou de létat de méthylation) de protéines pathologiques (par exemple, CD70, CD40L, et/ou KIR). La présente invention concerne en outre des kits pour détecter létat de méthylation de protéines pathologiques (par exemple, CD70, CD40L, et/ou KIR) et pour diagnostiquer, surveiller et/ou traiter des maladies (par exemple, une maladie inflammatoire auto-immune ou chronique, une maladie cardiaque et/ou un accident cérébrovasculaire).
Smart & Biggar
The Regents Of The University Of Michigan
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