Methods, compositions and kits for the detection and...

C - Chemistry – Metallurgy – 12 – Q

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C12Q 1/68 (2006.01) G01N 33/543 (2006.01) G01N 33/574 (2006.01) C12N 5/08 (2006.01)

Patent

CA 2404978

Compositions and methods for the therapy and diagnosis of cancer, such as breast cancer, are disclosed. Compositions may comprise one or more breast tumor proteins, immunogenic portions thereof, or polynucleotides that encode such portions. Alternatively, a therapeutic composition may comprise an antigen presenting cell that expresses a breast tumor protein, or a T cell that is specific for cells expressing such a protein. Such compositions may be used, for example, for the prevention and treatment of diseases such as breast cancer. Diagnostic methods based on detecting a breast tumor protein, or mRNA encoding such a protein, in a sample are also provided.

Cette invention a trait à des méthodes de traitement et de diagnostic du cancer, notamment du cancer du sein. Les compositions selon l'invention peuvent renfermer une ou plusieurs protéines de tumeur du sein, des fractions immunogènes de celles-ci ou des polynucléotides codant ces fractions. Dans une variante, la composition thérapeutique peut renfermer une cellule présentant un antigène exprimant une protéine de tumeur du sein ou un lymphocyte T spécifique de cellules exprimant cette protéine. Il est possible d'utiliser ces compositions, par exemple, aux fins de la prévention et du traitement de maladies telles que le cancer du sein. L'invention concerne également des méthodes diagnostiques axées sur la détection dans un prélèvement de protéines de tumeur du sein ou d'un ARN messager codant ces protéines.

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