Methods, compounds, and compositions for treating metabolic...

A - Human Necessities – 61 – K

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A61K 31/10 (2006.01) A61P 3/08 (2006.01) A61P 3/10 (2006.01)

Patent

CA 2673022

Disclosed herein are methods, compounds and compositions for preventing or treating a pancreatic disorder, including diabetes mellitus (e.g. type 1 and/or type 2 diabetes). The invention generally includes administering to a subject 1,3-propanedisulfonic acid or a pharmaceutically acceptable salt thereof, e.g., 1,3-propanedisulfonic acid sodium salt. The invention also relates to methods, compounds and compositions for improving or at least stabilizing pancreatic function(s) and for the prevention and/or treatment of metabolic syndrome and its components. The invention further relates to methods, compounds and compositions for the prevention and/or treatment of dyslipidemia, and more particularly for reducing levels of harmful serum lipid levels, especially cholesterol and triglycerides in patients in need thereof, including diabetic patients.

La présente invention concerne des procédés, des composés et des compositions pour prévenir ou traiter un trouble pancréatique, notamment un diabète sucré (par ex. diabète de type 1 et/ou de type 2). Cette invention consiste généralement à administrer à un sujet de l'acide 1,3-propane disulfonique ou un sel de celui-ci, pharmaceutiquement acceptable, par exemple un sel de sodium d'acide 1,3-propane disulfonique. Cette invention concerne également des procédés, des composés et des compositions pour améliorer ou au moins stabiliser une ou plusieurs fonctions pancréatiques et pour prévenir et/ou traiter un syndrome métabolique et ses composantes. Elle concerne en outre des procédés, des composés et des compositions pour prévenir et/ou traiter une dyslipidémie, en particulier pour réduire le taux de lipides sériques nocifs, notamment le cholestérol et les triglycérides, chez des patients concernés, y compris des patients diabétiques.

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