C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 277/44 (2006.01) A61P 35/00 (2006.01) C07C 235/84 (2006.01) C07D 231/54 (2006.01) C12Q 1/00 (2006.01) C12Q 1/68 (2006.01) C40B 30/06 (2006.01) C12N 15/113 (2010.01) A61K 31/166 (2006.01) A61K 31/416 (2006.01) A61K 31/426 (2006.01)
Patent
CA 2605166
This invention is directed to methods for screening and identification of compounds capable of selectively eliminating cancer cells with specific loss- of- function alterations, including but not limited to mutations, deletions, hypermethylations, and other types of gene silencing. This invention is also directed to novel compounds that selectively eliminate cancer cells with specific loss-of-f unction alterations. Furthermore, this invention is directed to methods for production and therapeutic use of compounds that selectively eliminate cancer cells with specific loss-of-function alterations.
Cette invention concerne des méthodes de criblage et d'identification de composés capables d'éliminer sélectivement des cellules cancéreuses à altérations avec perte de fonction spécifiques, y compris, de façon non exhaustive, des mutations, des délétions, des hyperméthylations et d'autres types de silençage génique. Cette invention concerne également de nouveaux composés éliminant sélectivement des cellules cancéreuses à altérations avec perte de fonction spécifiques. En outre, ladite invention se rapporte à des méthodes de production et à l'utilisation thérapeutique de composés éliminant sélectivement des cellules cancéreuses à altérations avec perte de fonction spécifiques.
Flynn Gary A.
Han Haiyong
von Hoff Daniel D.
Wang Hong
Smart & Biggar
Tgen
The University Of Arizona
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