Methods for adapting mammalian cells

Details Methods for adapting mammalian cells Methods for adapting mammalian cells

C - Chemistry, Metallurgy

12

N

C12N 5/00 (2006.01)

Patent

CA 2628340

Methods of adapting cells, e.g., mammalian cells, to a cell culture process are provided. When the adapted cells are genetically modified and used for protein production, they exhibit beneficial characteristics, such as being able to attain higher cell densities and/or achieve a higher overall yield of the produced protein.

La présente invention concerne des procédés d'adaptation de cellules, par exemple, de cellules de mammifère, à un processus de culture de cellules. Lorsque les cellules adaptées sont génétiquement modifiées et utilisées pour la production de protéine, elles présentent des caractéristiques bénéfiques, telles que la capacité à atteindre des densités de cellules plus élevées et/ou obtenir un rendement total plus élevé de la protéine produite.

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