A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 9/08 (2006.01) A61K 9/10 (2006.01)
Patent
CA 2534997
The present invention relates, in part, to the discovery that a pharmaceutical composition comprising aripiprazole and a carrier administered in a bolus injection resulted in an extended release profile similar to that obtained by the injection of a poly lactide-co-glycolide microsphere formulation containing the active agent. This surprising result suggests that pharmacologically beneficial extended release formulations without the complexities and expense associated with the manufacture microspheres.
L'invention concerne en partie la découverte du fait qu'une composition pharmaceutique comprenant de l'aripiprazole et un excipient, administrée dans une injection bolus donne lieu à un profil de libération élargi, similaire à celui obtenu par injection d'une formulation de microsphères de poly-lactide-co-glycolide, contenant le principe actif. Ce résultat étonnant laisse à penser qu'il est possible d'obtenir des formulations à libération élargie, bénéfiques sur le plan pharmaceutique, sans les aspects techniques complexes et les dépenses associés à la fabrication de microsphères.
Alkermes Inc.
Alkermes Controlled Therapeutics II
Gowling Lafleur Henderson Llp
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