A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/25 (2006.01) A61K 9/14 (2006.01) A61K 9/16 (2006.01)
Patent
CA 2124277
ABSTRACT A method for administering biological agents to eggs is disclosed which comprises providing the agents in a particulate carrier and injecting the carrier into the air cells of the eggs. The egg is preferably maintained in a vertical position with the air cell on top to facilitate migration of the particulate carrier between the inner and outer membranes which define the air cell, to the lower end of the egg. The particulate carrier releases the biological agent to the surrounding fluid and blood vessels. In addition, the carrier is embodied in the bird upon hatching from the egg, and therefore is available to continue to release the biological agent to the bird posthatch. Also disclosed is a composition of polyester microparticles containing bioactive polypeptide agents and methods for preparing the composition and administering bioactive agents. The composition comprises biocompatible, biodegradable microparticles having a polyester matrix and from about 5% to about 25% by weight of a biologically active, water-soluble polypeptide dispersed throughout the matrix, the polypeptide selected fom the group consisting of growth hormone releasing factor, synthetic analogs of growth hormone releasing factor, and pharmacologically active fragments thereof. The method for preparing the composition includes dissolving polyester in an organic solvent; suspending a biologically active agent in the polyester solution; emulsifying the suspension into an aqueous medium in which the agent is insoluble and evaporating the solvent from the emulsion to produce microparticles. The method for administering a bioactive agent to an organism involves suspending the microparticles in a suitable liquid and injecting the organism.
Craft Libbey S.
Ferguson Thomas H.
Heiman Mark L.
Thompson William W.
Eli Lilly And Company
Gowling Lafleur Henderson Llp
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