Methods for administering dpd inhibitors in combination with...

Details Methods for administering dpd inhibitors in combination with... Methods for administering dpd inhibitors in combination with...

A - Human Necessities

61

K

A61K 31/505 (2006.01)

Patent

CA 2587514

Methods for improved administration and dosing of DPD inhibitors in combination with 5-FU and/or 5-FU prodrugs are provided, comprising first administering to a patient in need thereof a DPD inhibitor that substantially eliminates activity of the enzyme and thereafter administering 5-FU or a 5-FU prodrug, wherein the level of 5-FU or 5-FU prodrug is in substantial excess of DPD inhibitor in the patient.

L'invention concerne des méthodes améliorées d'administration et de dosage d'inhibiteurs de DPD en association avec 5-FU et/ou des promédicaments de 5-FU. Ces méthodes consistent d'abord à administrer à un patient nécessitant un tel traitement un inhibiteur de DPD qui élimine sensiblement l'activité de l'enzyme. Elles consistent ensuite à administrer 5-FU ou un promédicament de 5-FU, le taux de 5-FU ou du promédicament de 5-FU présentant un excès sensible de l'inhibiteur de DPD chez le patient.

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