Methods for aiding in the diagnosis of alzheimer's disease...

G - Physics – 01 – N

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G01N 33/68 (2006.01) G01N 33/53 (2006.01) G01N 33/543 (2006.01)

Patent

CA 2205359

This invention provides methods useful in aiding in the diagnosis of Alzheimer's disease. The methods involve measuring the amount of amyloid-.beta. peptide (x- >=41) in the cerebrospinal fluid of a patient. High levels of the peptide generally are inconsistent with a diagnosis of Alzheimer's. Low levels of the peptide are consistent with the disease and, with other tests, can provide a positive diagnosis. Other methods involve measuring the amounts of both A.beta.(x -. gtoreq.41) and tau. Low levels of A.beta.(x- >=41) and high levels of tau are a positive indicator of Alzheimer's disease, while high levels of A.beta.(x->=41) and low levels of tau are a negative indication of Alzheimer's disease.

L'invention porte sur une méthode d'assistance au diagnostic de la maladie d'Alzheimer par mesure de la quantité de peptide amyloïde- beta (x- >/=41) présente dans le fluide cérébro-spinal du patient. Des taux élevés dudit peptide sont généralement incompatibles avec la maladie, alors que des taux faibles sont indicateurs de la maladie. On peut ainsi, en association avec d'autres tests, émettre un diagnostic positif. D'autres méthodes consistent à mesurer à la fois les niveaux d'A( beta (x- >/=41) et de tau, des taux faibles du premier et des taux élevés du second correspondant à une indication positive de la maladie, alors que des taux élevés d'A beta (x- >/=41) et des taux faibles de tau correspondent à une indication négative de la maladie.

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