A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 39/395 (2006.01) A61K 35/12 (2006.01) C12Q 1/02 (2006.01) C12N 5/06 (2006.01) C12N 5/08 (2006.01)
Patent
CA 2545248
The present invention satisfies the need in the art by providing methods for altering hematopoietic progenitor cell adhesion and/or migration to a target tissue, and for altering hematopoietic progenitor cell differentiation into a second cell type. The invention also provides methods for screening test compounds for altering the level of hematopoietic progenitor cell adhesion and/or migration to a target tissue, and for altering hematopoietic progenitor cell differentiation into a second cell type. The invention further provides methods for isolating hematopoietic progenitor cells.
La présente invention, qui répond à un besoin de la technique, a trait à des procédés permettant de modifier l'adhésion de cellules progénitrices hématopoïétiques à un tissu cible et/ou leur migration vers ce dernier, et de modifier la différenciation de cellules progénitrices hématopoïétiques en un second type cellulaire. L'invention concerne aussi des procédés de criblage de composés d'essai permettant de modifier le niveau d'adhésion de cellules progénitrices hématopoïétiques à un tissu cible et/ou leur niveau de migration vers ce dernier, et de modifier la différenciation de cellules progénitrices hématopoïétiques en un second type cellulaire. L'invention a également trait à des procédés permettant d'isoler des cellules progénitrices hématopoïétiques.
Smart & Biggar
The Regents Of The University Of California
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