Methods for altering surface characteristics of microspheres

Details Methods for altering surface characteristics of microspheres Methods for altering surface characteristics of microspheres

G - Physics

01

N

G01N 33/543 (2006.01) G01N 33/546 (2006.01) G01N 33/58 (2006.01)

Patent

CA 2583474

Various methods for forming dyed microspheres are provided. One method includes activating a chemical structure coupled to a dye using heat or light to form a reaction intermediate in the presence of a microsphere. The reaction intermediate covalently attaches to a polymer of the microsphere thereby coupling the dye to the polymer and forming the dyed microsphere. Additional methods are provided for forming a dyed microsphere coupled to a molecule. These methods include dyeing the microspheres as described above in addition to synthesizing the molecule on an outer surface of the dyed microspheres. A population of dyed microspheres is also provided. Each of the dyed microspheres of the population includes a dye attached to a polymer of each of the dyed microspheres by a chemical structure. A coefficient of variation in dye characteristics of the population of dyed microspheres attributable to the dye is less than about 10%.

L'invention concerne divers procédés permettant de former des microsphères colorées. Un procédé de l'invention consiste à activer une structure chimique couplée à un colorant en faisant intervenir de la chaleur ou de la lumière afin que soit formé un intermédiaire de réaction en présence d'une microsphère. Cet intermédiaire de réaction se lie par covalence à un polymère de la microsphère, ce qui permet de raccorder le colorant au polymère et de former la microsphère colorée. L'invention concerne d'autres procédés permettant de former une microsphère colorée couplée à une molécule. Ces procédés consistent à colorer lesdites microsphères et à synthétiser la molécule sur une surface extérieure des microsphères colorées. L'invention concerne également une population de microsphères colorées. Chacune des microsphères colorées de la population comprend un colorant relié à un polymère de chacune desdites microsphères colorées par une structure chimique. Un coefficient de variation associé aux caractéristiques de colorant de la population de microsphères colorées pouvant être attribué au colorant est inférieur à environ 10 %.

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