G - Physics – 01 – N
Patent
G - Physics
01
N
G01N 33/72 (2006.01)
Patent
CA 2654981
The invention provides enzymatic methods for direct determination of percentage of glycated hemoglobin in blood samples without the need of a separated measurement of total hemoglobin content in blood samples. The methods utilizes one or two different types of oxidizing agents which selectively oxidize low-molecular weight reducing substances and high-molecular weight (mainly hemoglobin) reducing substances in blood samples, coupled with enzymatic reactions catalyzed by proteases, fructosyl amino acid oxidase, and peroxidase. The invention provides kits for performing the methods of the invention.
La présente invention concerne un procédé enzymatiques d'évaluation directe du pourcentage d'hémoglobine glycatée dans les échantillons sanguins sans passer par une mesure séparée de l'hémoglobine totale. Le procédé utilise un ou deux types différentes d'agents oxydants qui oxydent sélectivement les substances réductrices de faible poids moléculaire et les substances réductrices de poids moléculaire élevé, essentiellement l'hémoglobine dans les échantillons sanguins, couplées à des réactions enzymatiques catalysées par des protéases, l'oxydase de l'acide aminé du fructosyle, et la péroxydase. L'invention concerne également des nécessaires pour appliquer le procédé de l'invention.
Datta Abhijit
Liu Limin
Yuan Chong-Sheng
Borden Ladner Gervais Llp
General Atomics
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